Hydrochloric Acid → HCID 86761677, compound

Participants

Reaction Conditions

Reaction Steps

70.0 mg (0.2 mmol) tert. Butyl (2S,4R)-2-aminomethyl-4-[(5-chloro-thiophene-2-carbonyl)-amino]-pyrrolidine-1-carboxylate are dissolved in 5 ml DCM and combined successively at −10° C. with 15.4 μl (0.2 mmol) acetyl chloride and 67 μl (0.4 mmol) DIPEA. The mixture is stirred for two hours at 0° C. Then it is made weakly acidic by the careful addition of dil. hydrochloric acid and extracted three times with ethyl acetate. The combined organic phases are dried on sodium sulphate, filtered and evaporated down i. vac.

Provenance & Evidence