HCID 68714946, compound → HCID 57994383, compound

Participants

Role	Name	HCID	Charge
Reactant	HCID 68714946	HCID 68714946	—
Reactant	HCID 178418348	HCID 178418348	—
Catalyst	Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)	HCID 24350	—
Catalyst	HCID 91886321	HCID 91886321	—
Catalyst	HCID 178418476	HCID 178418476	—
Product	HCID 57994383	HCID 57994383	70%

Reaction Steps

9-Methoxy-7-methyl-4-trifluoromethanesulfonyl-5H-furo[3,2-g]chromen-5-one (324 mg, 1.0 mmol), ZnBr2.H2O (1.04 g, 4.0 mmol), CuI (28 mg, 0.15 mmol), PdCl2(PPh3)2 (84 mg, 0.12 mmol) and MeLi (2.5 ml of 1.6 M in diethylether, 4.0 mmol) were treated as described under General Procedure G (Step 2) to afford the title compound (Yield 70%). 1H NMR (300 MHz, CDCl3): δ 2.38 (s, 3H, Me), 2.94 (s, 3H, Me), 4.21 (s, 3H, OMe), 6.05 (s, 1H), 6.91 (d, J=2.4, 1H), 7.65 (d, J=2.4, 1H). MS (ES) m/z: 244.9 (M+H+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08309545B2
Source dataset	uspto-grants-2012_11
ORD ID	ord-d0cbebc808154bd78e1a199c5abde9d7
Source note	uspto-grants-2012_11