HCID 12838740, compound → HCID 68709642, compound

Participants

Reaction Steps

4,9-Dihydroxy-7-methyl-5H-furo[3,2-g]chromen-5-one was reacted with 1-bromo-3-(4-fluorophenyl)propane according to General Procedure A to give 9-(3-[4-fluorophenyl]propoxy)-4-hydroxy-5H-furo[3,2-g]chromen-5-one, that was further reacted according to General Procedure G step 1-3, to provide the title compound in 22% yield (over 4 steps). 1H NMR (300 MHz, CDCl3): δ 2.04-2.14 (m, 2H), 2.53 (s, 3H, CH3), 2.63 (s, 3H, CH3), 2.83 (t, J=7.8, 2H), 4.34 (t, J=6.3, 2H), 6.73 (d, J=2.1, 1H), 6.94 (t J=8.7 Hz, 2H), 7.13-7.18 (m, 2H), 7.50 (d, J=2.1 Hz, 1H), 8.98 (s, 1H, OH). MS (ES) m/z: 342.9 (M+H+).

Provenance & Evidence