HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Methyl (4R)-4-[(2-ethoxy-7-methoxy-6-vinylquinolin-4-yl)oxy]-L-prolinate dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-t-Butyl 2-methyl (2S,4R)-4-[(2-ethoxy-7-methoxy-6-vinylquinolin-4-yl)oxy]pyrrolidine-1,2-dicarboxylate | HCID 58091453 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl (4R)-4-[(2-ethoxy-7-methoxy-6-vinylquinolin-4-yl)oxy]-L-prolinate dihydrochloride | HCID 86640851 | — |
Reaction Steps
HCl (g) was bubbled for 10 minutes through a solution of the product from Step 1 (3.90 g, 8.25 mmol) in DCM (83 mL). The solution stirred for 1 hour, and the DCM was removed in vacuo to give 3.55 g of the title compound as a white powder. LRMS ESI+ (M+H−2(HCl))+ 373.1, calcd for C20H25N2O5: 373.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309540B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-cc953438ae704a7bae4fbcc8d219c396 |
| Source note | uspto-grants-2012_11 |