HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene → HCID 178505618, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene | HCID 241 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Ethynyl-2-fluorobenzene | HCID 643358 | — |
| Reactant | (2-Iodophenyl)hydrazine | HCID 1381941 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 178505618 | HCID 178505618 | — |
Reaction Steps
Under argon, 200 mg (0.86 mmol) of 2-iodophenylhydrazine, 133 mg (1.11 mmol) of 2-fluoro-phenylacetylene, 30 mg (0.04 mmol) of bis(triphenylphosphine)palladium(II) chloride and 8 mg (0.04 mmol) of copper(I) iodide are introduced into a mixture of 1.5 ml of triethylamine and 3.5 ml of benzene. The mixture is heated to reflux for 4 h and then diluted with ethyl acetate and filtered. The filtrate is concentrated and the residue is purified by preparative HPLC. 36 mg (18% of theory) of the desired product are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309551B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-4e37bd05a0c5484e89543db783f78968 |
| Source note | uspto-grants-2012_11 |