HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1875445Generated: October 29, 2026
2,3-Dichloropyrazine → HCID 59177859, compound
https://huagongshe.com/reaction/1875445
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2,3-Dichloropyrazine | HCID 78575 | — |
| Reactant | 1-Ethynyl-2-fluorobenzene | HCID 643358 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 59177859 | HCID 59177859 | — |
Reaction Steps
49 mg (0.26 mmol) of copper(I) iodide and 179 mg (0.26 mmol) of bis(triphenyl-phosphine)palladium(II) chloride are added to a solution of 760 mg (5.10 mmol) of 2,3-dichloropyrazine in 27 ml of triethylamine and cooled to 0° C. Then 919 mg (7.65 mmol) of 2-fluoro-phenylacetylene are added dropwise, and the mixture is heated at 80° C. for 3 h. It is then filtered and concentrated. The residue is purified by preparative HPLC. 717 mg (60% of theory) of the title compound are obtained as pale beige crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08309551B2 |
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| Source dataset | uspto-grants-2012_11 |
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| ORD ID | ord-4252ff979c4344ef9fe2a9d9bf18f291 |
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| Source note | uspto-grants-2012_11 |
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