反应详情

温度

50 °C

690 mg (1.42 mmol) of 2-[3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]-5-nitropyrimidine-4,6-diamine from example 15A are dissolved in 120 ml of pyridine. 270 mg of 10% palladium on activated carbon are added, and hydrogenation is carried out under a hydrogen pressure of 3.5 bar for 15 h. The catalyst is then filtered off and washed with ethanol. The residue after concentration to dryness is stirred with ethanol at 50° C. and filtered off with suction. 378 mg (76% of theory) of the desired product are obtained. A further 92 mg (18% of theory) of the target compound can be obtained from the filtrate by purifying by preparative HPLC.

1. customfor 15 h
2. filtrationThe catalyst is then filtered off
3. washwashed with ethanol
4. concentrationThe residue after concentration to dryness
5. filtrationfiltered off with suction