Benzyl 3-Bromopropyl Ether → HCID 11598875, compound

HRID 1875585Notes

Reaction equation

HRID 1875585 reaction equation
[N:1]12[CH2:8][CH2:7][C:4]([C:9]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[OH:10])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[C:23]1([CH2:29][O:30][CH2:31][CH2:32][CH2:33][Br:34])[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>CC#N>[Br-:34].[OH:10][C:9]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[C:4]12[CH2:5][CH2:6][N+:1]([CH2:33][CH2:32][CH2:31][O:30][CH2:29][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)([CH2:2][CH2:3]1)[CH2:8][CH2:7]2

Participants

4

Reactant 2

HCID 2776064Benzyl 3-Bromopropyl EtherHCID 239923851-Azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol

Product 1

HCID 11598875HCID 11598875, compoundYield 55.2%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Following the general procedure outlined in Example 4, 1-azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol (0.0677 g, 0.231 mmol) and 3-bromopropyl phenylmethyl ether (0.070 mL, 0.396 mmol) in 2 CH3CN/3 CHCl3 (4.0 mL) were reacted to give the desired product (0.0663 g, 55.2%). EI-MS m/z 442 (M+) Rt (2.23 min).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-0c63c8edfd454860ac511f10f251f0f5
Source dataset
uspto-grants-2012_11
Patent number
US08309572B2

Reaction notes

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