Phenethyl bromide → HCID 11641678, compound

HRID 1875605Notes

Reaction equation

HRID 1875605 reaction equation
[N:1]12[CH2:8][CH2:7][C:4]([C:9]([C:16]3[S:17][CH:18]=[CH:19][CH:20]=3)([C:11]3[S:12][CH:13]=[CH:14][CH:15]=3)[OH:10])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[Br:21][CH2:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>CO>[Br-:21].[OH:10][C:9]([C:16]1[S:17][CH:18]=[CH:19][CH:20]=1)([C:11]1[S:12][CH:13]=[CH:14][CH:15]=1)[C:4]12[CH2:5][CH2:6][N+:1]([CH2:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)([CH2:8][CH2:7]1)[CH2:2][CH2:3]2

Participants

4

Reactant 2

HCID 7666Phenethyl bromideHCID 688655991-Azabicyclo[2.2.2]oct-4-yl(di-2-thienyl)methanol

Product 1

HCID 11641678HCID 11641678, compoundYield 3,792.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Following the general procedure outlined in Example 4, 1-azabicyclo[2.2.2]oct-4-yl(di-2-thienyl)methanol (0.0658 g, 0.215 mmol) and (2-bromoethyl)benzene (0.050 mL, 0.366 mmol) in 1 MeOH/1 CHCl3 (4.0 mL) were reacted to give the desired product (0.051 4 g, 48.9%). EI-MS m/z 410 (M+) Rt (1.83 min).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-51963c79801c4494880d122bbe48659d
Source dataset
uspto-grants-2012_11
Patent number
US08309572B2

Reaction notes

Loading…