HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol → 4-[Hydroxy(diphenyl)methyl]-1-[3-({2-[(phenylmethyl)oxy]phenyl}oxy)propyl]-1-azoniabicyclo[2.2.2]octane bromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol | HCID 23992385 | — |
| Reactant | 1-(3-Bromopropoxy)-2-(benzyloxy)-benzene | HCID 53690636 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-[Hydroxy(diphenyl)methyl]-1-[3-({2-[(phenylmethyl)oxy]phenyl}oxy)propyl]-1-azoniabicyclo[2.2.2]octane bromide | HCID 68959881 | 71.4% |
Reaction Steps
Following the general procedure outlined in Example 3, 1-azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol (0.0492 g, 0.168 mmol) and 1-[(3-bromopropyl)oxy]-2-[(phenylmethyl)oxy]benzene (0.0706 g, 0.220 mmol) in 2 CH3CN/3 CHCl3 (4.0 mL) were reacted to give the desired product (0.0735 g, 71.4%). EI-MS m/z 533 (M+) Rt (2.25 min).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309572B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-fba06f88fcfa4099ab2595af99a0ef79 |
| Source note | uspto-grants-2012_11 |