HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Benzyloxy)-4-(3-bromopropoxy)benzene → 4-[Hydroxy(diphenyl)methyl]-1-[3-({4-[(phenylmethyl)oxy]phenyl}oxy)propyl]-1-azoniabicyclo[2.2.2]octane bromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Benzyloxy)-4-(3-bromopropoxy)benzene | HCID 11110031 | — |
| Reactant | 1-Azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol | HCID 23992385 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-[Hydroxy(diphenyl)methyl]-1-[3-({4-[(phenylmethyl)oxy]phenyl}oxy)propyl]-1-azoniabicyclo[2.2.2]octane bromide | HCID 11650225 | 83.3% |
Reaction Steps
Following the general procedure outlined in Example 3, 1-azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol (0.0479 g, 0.163 mmol) and 1-[(3-bromopropyl)oxy]-4-[(phenylmethyl)oxy]benzene (0.0730 g, 0.227 mmol) in 2 CH3CN/3 CHCl3 (4.0 mL) were reacted to give the desired product (0.0833 g, 83.3%). EI-MS m/z 534 (M+) Rt (2.31 min).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309572B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-f288635b2ea141719b8bf9c9517e38bf |
| Source note | uspto-grants-2012_11 |