1-Bromo-3-methoxypropane → HCID 42625941, compound

HRID 1875622Notes

Reaction equation

HRID 1875622 reaction equation
[N:1]12[CH2:8][CH2:7][C:4]([C:9]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[OH:10])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[CH3:23][O:24][CH2:25][CH2:26][CH2:27][Br:28]>CC#N>[Br-:28].[OH:10][C:9]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[C:4]12[CH2:5][CH2:6][N+:1]([CH2:27][CH2:26][CH2:25][O:24][CH3:23])([CH2:2][CH2:3]1)[CH2:8][CH2:7]2

Participants

4

Reactant 2

HCID 5245511-Bromo-3-methoxypropaneHCID 239923851-Azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol

Product 1

HCID 42625941HCID 42625941, compoundYield 86.1%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Following the general procedure outlined in Example 3, 1-azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol (0.0632 g, 0.215 mmol) and 3-bromopropyl methyl ether (0.0461 g, 0.301 mmol) in 2 CH3CN/3 CHCl3 (4.0 mL) were reacted to give the desired product (0.0826 g, 86.0%). EI-MS m/z 366 (M+) Rt (1.55 min).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-faa10655054149c4b059d9e0411ad05f
Source dataset
uspto-grants-2012_11
Patent number
US08309572B2

Reaction notes

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