HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene, ((2-bromoethoxy)methyl)- → 4-[Bis(4-fluorophenyl)(hydroxy)methyl]-1-{2-[(phenylmethyl)oxy]ethyl}-1-azoniabicyclo[2.2.2]octane bromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene, ((2-bromoethoxy)methyl)- | HCID 73833 | — |
| Reactant | 1-Azabicyclo[2.2.2]oct-4-yl[bis(4-fluorophenyl)]methanol | HCID 68959129 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-[Bis(4-fluorophenyl)(hydroxy)methyl]-1-{2-[(phenylmethyl)oxy]ethyl}-1-azoniabicyclo[2.2.2]octane bromide | HCID 11592004 | 66.3% |
Reaction Steps
Following the general procedure outlined in Example 3, 1-azabicyclo[2.2.2]oct-4-yl[bis(4-fluorophenyl)]methanol (0.0489 g, 0.148 mmol) and 2-bromoethyl phenylmethyl ether (0.0352 mL, 0.222 mmol) in 2 CH3CN/3 CHCl3 (4.0 mL) were reacted to give the desired product (0.0534 g, 66.1%). EI-MS m/z 464 (M+) Rt (1.99 min).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309572B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-8351de0c40f5462283cb7a1f7b6f907c |
| Source note | uspto-grants-2012_11 |