(R)-3-(2-(2-(hydroxymethyl)pyrrolidin-1-yl)ethyl)-5-methylisoquinolin-1(2H)-one → HCID 131730056, compound

Participants

Reaction Conditions

Reaction Steps

To a solution (7 mL) of a free form (700 mg) of (R)-3-[2-(2-hydroxymethylpyrrolidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one in ethanol was added dropwise 2M sulfuric acid ethanol solution (612 μL) with stirring on an oil bath at 50° C. The bath was removed, ethyl acetate (11.5 mL) and seed crystals were added with stirring at room temperature to allow precipitation of crystals. After stirring under ice-cooling, the crystals were collected through filtration, washed with ethyl acetate/ethanol (2:1) and dried under reduced pressure at 50° C. for 28 hr to give the title compound (714 mg).

Provenance & Evidence