(R)-3-(2-(2-(hydroxymethyl)pyrrolidin-1-yl)ethyl)-5-methylisoquinolin-1(2H)-one → HCID 86653874, compound

HRID 1875705Notes

Reaction equation

HRID 1875705 reaction equation
[OH:1][CH2:2][C@H:3]1[CH2:7][CH2:6][CH2:5][N:4]1[CH2:8][CH2:9][C:10]1[NH:11][C:12](=[O:21])[C:13]2[C:18]([CH:19]=1)=[C:17]([CH3:20])[CH:16]=[CH:15][CH:14]=2.C(O)C.[C:25]([OH:34])(=[O:33])[C@@H:26]([C@H:28]([C:30]([OH:32])=[O:31])[OH:29])[OH:27]>C(O)C>[OH2:1].[C:30]([C@@H:28]([C@H:26]([C:25]([OH:34])=[O:33])[OH:27])[OH:29])([OH:32])=[O:31].[OH:1][CH2:2][C@H:3]1[CH2:7][CH2:6][CH2:5][N:4]1[CH2:8][CH2:9][C:10]1[NH:11][C:12](=[O:21])[C:13]2[C:18]([CH:19]=1)=[C:17]([CH3:20])[CH:16]=[CH:15][CH:14]=2

Participants

4

Reactant 2

HCID 10424118(R)-3-(2-(2-(hydroxymethyl)pyrrolidin-1-yl)ethyl)-5-methylisoquinolin-1(2H)-oneHCID 86653875HCID 86653875, compound

Product 1

HCID 86653874HCID 86653874, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution (500 μL) of a free form (52 mg) of (R)-3-[2-(2-hydroxymethylpyrrolidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one in ethanol was added dropwise 100 mg/mL L-tartaric acid ethanol solution (272 μL) under ice-cooling with stirring and the mixture was left standing for 1 hr. The resulting precipitate was collected by filtration, washed with cold ethanol (2 mL) and dried under reduced pressure at 50° C. for 10 hr to give the title compound (44 mg).

Workup

  1. temperaturecooling
  2. waitthe mixture was left
  3. filtrationThe resulting precipitate was collected by filtration
  4. washwashed with cold ethanol (2 mL)
  5. customdried under reduced pressure at 50° C. for 10 hr

Sources & evidence

ORD record
ord-20caf4b7e0104a6f9bcb07330dafb91f
Source dataset
uspto-grants-2012_11
Patent number
US08309573B2

Reaction notes

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