Cyclopropanemethanol → HCID 51042708, compound

HRID 1875730Notes

Reaction equation

HRID 1875730 reaction equation
[CH2:1]([N:8]1[C:12]2[CH:13]=[C:14]([F:18])[C:15]([F:17])=[CH:16][C:11]=2[N:10]=[C:9]1[C:19]1[C:20]([O:25][CH2:26][C:27]2[CH:32]=[CH:31]C=CC=2Cl)=[N:21][CH:22]=[CH:23][CH:24]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1(CO)CC1>>[CH2:1]([N:8]1[C:12]2[CH:13]=[C:14]([F:18])[C:15]([F:17])=[CH:16][C:11]=2[N:10]=[C:9]1[C:19]1[C:20]([O:25][CH2:26][CH:27]2[CH2:32][CH2:31]2)=[N:21][CH:22]=[CH:23][CH:24]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 75644CyclopropanemethanolHCID 51042706HCID 51042706, compound

Product 1

HCID 51042708HCID 51042708, compound

Procedure

The title compound was prepared in analogy to Example 1, from 1-benzyl-2-(2-chloro-pyridin-3-yl)-5,6-difluoro-1H-benzoimidazole (Example 6, intermediate) and cyclopropyl-methanol (CAS Reg. No. 2516-33-8). Colorless powder (23%). MS (Turbo Spray): m/z=392.2 (M+H).

Sources & evidence

ORD record
ord-d4cd3bb9f9f2440baba23fdc862a80c4
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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