Methyl 4-(hydroxymethyl)benzoate → HCID 67049874, compound

HRID 1875731Notes

Reaction equation

HRID 1875731 reaction equation
[CH2:1]([N:8]1[C:12]2[CH:13]=[C:14]([F:18])[C:15]([F:17])=[CH:16][C:11]=2[N:10]=[C:9]1[C:19]1[C:20]([O:25][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2Cl)=[N:21][CH:22]=[CH:23][CH:24]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:34][O:35][C:36](=[O:45])C1C=CC(CO)=CC=1>>[CH3:34][O:35][C:36](=[O:45])[C:30]1[CH:31]=[CH:32][C:27]([CH2:26][O:25][C:20]2[C:19]([C:9]3[N:8]([CH2:1][C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=4)[C:12]4[CH:13]=[C:14]([F:18])[C:15]([F:17])=[CH:16][C:11]=4[N:10]=3)=[CH:24][CH:23]=[CH:22][N:21]=2)=[CH:28][CH:29]=1

Participants

3

Reactant 2

HCID 81325Methyl 4-(hydroxymethyl)benzoateHCID 51042706HCID 51042706, compound

Product 1

HCID 67049874HCID 67049874, compound

Procedure

The title compound was prepared in analogy to Example 4, intermediate, from 1-benzyl-2-(2-chloro-pyridin-3-yl)-5,6-difluoro-1H-benzoimidazole (Example 6, intermediate) and 4-hydroxymethyl-benzoic acid methyl ester (CAS Reg. No. 6908-41-4). Brown sticky solid (15%). MS (Turbo Spray): m/z=386.2 (M+H).

Sources & evidence

ORD record
ord-865504d44b2940db8be80fbaa0a55c06
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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