HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropanemethanol → 1-(3-Chloro-benzyl)-2-(2-cyclopropylmethoxy-pyridin-3-yl)-5,6-difluoro-1H-benzoimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropanemethanol | HCID 75644 | — |
| Reactant | 1-(3-Chloro-benzyl)-2-[2-(2-chloro-benzyloxy)-pyridin-3-yl]-5,6-difluoro-1H-benzoimidazole | HCID 51039469 | — |
| Product | 1-(3-Chloro-benzyl)-2-(2-cyclopropylmethoxy-pyridin-3-yl)-5,6-difluoro-1H-benzoimidazole | HCID 51039471 | — |
Reaction Steps
The title compound was prepared in analogy to Example 1, from 1-(3-chloro-benzyl)-2-(2-chloro-pyridin-3-yl)-5,6-difluoro-1H-benzoimidazole (Example 11, intermediate) and cyclopropyl-methanol (CAS Reg. No. 2516-33-8). Colorless powder (20%). MS (Turbo Spray): m/z=426.2 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309581B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-95ebdef9fc0a46508e53b7af26f029f1 |
| Source note | uspto-grants-2012_11 |