HCID 51042485, compound → 3-[1-(3-chloro-benzyl)-5,6-difluoro-1H-benzoimidazol-2-yl]-pyridin-2-ol

HRID 1875738Notes

Reaction equation

HRID 1875738 reaction equation
C1(CN2C3C=C(F)C(F)=CC=3N=C2C2C(OCC3CCCC3)=NC=CC=2)CCCCC1.[Cl:32][C:33]1[CH:34]=[C:35]([CH:64]=[CH:65][CH:66]=1)[CH2:36][N:37]1[C:41]2[CH:42]=[C:43]([F:47])[C:44]([F:46])=[CH:45][C:40]=2[N:39]=[C:38]1[C:48]1[C:49]([O:54]CC2C=CC(OC)=CC=2)=[N:50][CH:51]=[CH:52][CH:53]=1>>[Cl:32][C:33]1[CH:34]=[C:35]([CH:64]=[CH:65][CH:66]=1)[CH2:36][N:37]1[C:41]2[CH:42]=[C:43]([F:47])[C:44]([F:46])=[CH:45][C:40]=2[N:39]=[C:38]1[C:48]1[C:49]([OH:54])=[N:50][CH:51]=[CH:52][CH:53]=1

Participants

3

Reactant 2

HCID 51042485HCID 51042485, compoundHCID 670499571-(3-chloro-benzyl)-5,6-difluoro-2-[2-(4-methoxy-benzyloxy)-pyridin-3-yl]-1H-benzoimidazole

Product 1

HCID 1785177073-[1-(3-chloro-benzyl)-5,6-difluoro-1H-benzoimidazol-2-yl]-pyridin-2-ol

Procedure

The title compound was prepared in analogy to Example 5, intermediate b, from 1-(3-chloro-benzyl)-5,6-difluoro-2-[2-(4-methoxy-benzyloxy)-pyridin-3-yl]-1H-benzoimidazole. Colorless powder (27%). MS (Turbo Spray): m/z=372.3 (M+H).

Sources & evidence

ORD record
ord-f5dc7902ba0248bf81a472cccf25fbea
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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