HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxybenzyl alcohol → 1-(3-chloro-benzyl)-5,6-difluoro-2-[2-(4-methoxy-benzyloxy)-pyridin-3-yl]-1H-benzoimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxybenzyl alcohol | HCID 7738 | — |
| Reactant | 1-(3-Chloro-benzyl)-2-[2-(2-chloro-benzyloxy)-pyridin-3-yl]-5,6-difluoro-1H-benzoimidazole | HCID 51039469 | — |
| Product | 1-(3-chloro-benzyl)-5,6-difluoro-2-[2-(4-methoxy-benzyloxy)-pyridin-3-yl]-1H-benzoimidazole | HCID 67049957 | — |
Reaction Steps
The title compound was prepared in analogy to Example 5, intermediate c, from 1-(3-chloro-benzyl)-2-(2-chloro-pyridin-3-yl)-5,6-difluoro-1H-benzoimidazole (Example 11, intermediate) and (4-methoxy-phenyl)-methanol (CAS Reg. No. 105-13-5). Off-white powder (87%). MS (Turbo Spray): m/z=492.3 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309581B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-88dfc1d5e3d7447da88032a3e6c42f39 |
| Source note | uspto-grants-2012_11 |