(Bromomethyl)cyclopentane → HCID 58209278, compound

HRID 1875747Notes

Reaction equation

HRID 1875747 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:9]2[N:13]([CH2:14][CH:15]3[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]3)[C:12]3[CH:21]=[C:22]([F:26])[C:23]([F:25])=[CH:24][C:11]=3[N:10]=2)=[C:6]([OH:8])[CH:7]=1.Br[CH2:28][CH:29]1[CH2:33][CH2:32][CH2:31][CH2:30]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:9]2[N:13]([CH2:14][CH:15]3[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]3)[C:12]3[CH:21]=[C:22]([F:26])[C:23]([F:25])=[CH:24][C:11]=3[N:10]=2)=[C:6]([O:8][CH2:28][CH:29]2[CH2:33][CH2:32][CH2:31][CH2:30]2)[CH:7]=1

Participants

3

Reactant 2

HCID 12723264(Bromomethyl)cyclopentaneHCID 1363784785-chloro-2-(1-cyclohexylmethyl-5,6-difluoro-1H-benzoimidazol-2-yl)-phenol

Product 1

HCID 58209278HCID 58209278, compound

Procedure

The title compound was prepared in analogy to Example 19, from 5-chloro-2-(1-cyclohexylmethyl-5,6-difluoro-1H-benzoimidazol-2-yl)-phenol (Example 19, intermediate a) and bromomethyl-cyclopentane (CAS Reg. No. 3814-30-0). Colorless powder (41%). MS (Turbo Spray): m/z=459.2 (M+H).

Sources & evidence

ORD record
ord-da0a4f11553e40af8da8d8eddeae1ea5
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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