Ethyl 6-bromohexanoate → 6-[5-Chloro-2-(1-cyclohexylmethyl-5,6-difluoro-1H-benzoimidazol-2-yl)-phenoxy]-hexanoic acid ethyl ester
Reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:9]2[N:13]([CH2:14][CH:15]3[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]3)[C:12]3[CH:21]=[C:22]([F:26])[C:23]([F:25])=[CH:24][C:11]=3[N:10]=2)=[C:6]([OH:8])[CH:7]=1.[CH2:27]([O:29][C:30](=[O:37])[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]Br)[CH3:28]>>[CH2:27]([O:29][C:30](=[O:37])[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][O:8][C:6]1[CH:7]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=1[C:9]1[N:13]([CH2:14][CH:15]2[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]2)[C:12]2[CH:21]=[C:22]([F:26])[C:23]([F:25])=[CH:24][C:11]=2[N:10]=1)[CH3:28]Participants
3
Procedure
The title compound was prepared in analogy to Example 5, intermediate a, from 5-chloro-2-(1-cyclohexylmethyl-5,6-difluoro-1H-benzoimidazol-2-yl)-phenol (Example 19, intermediate a) and (6-bromo-hexanoic acid ethyl ester CAS Reg. No. 25542-62-5). Brown sticky solid (70%). MS (Turbo Spray): m/z=519.0 (M+H).
Sources & evidence
- ORD record
- ord-e02a667e04c747c59696c06091ee4c11
- Source dataset
- uspto-grants-2012_11
- Patent number
- US08309581B2
Reaction notes
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