Methyl 4-(2-bromoethyl)benzoate → HCID 67049872, compound

HRID 1875754Notes

Reaction equation

HRID 1875754 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:9]2[N:13]([CH2:14][CH:15]3[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]3)[C:12]3[CH:21]=[C:22]([F:26])[C:23]([F:25])=[CH:24][C:11]=3[N:10]=2)=[C:6]([OH:8])[CH:7]=1.[CH3:27][O:28][C:29](=[O:39])[C:30]1[CH:35]=[CH:34][C:33]([CH2:36][CH2:37]Br)=[CH:32][CH:31]=1>>[CH3:27][O:28][C:29](=[O:39])[C:30]1[CH:35]=[CH:34][C:33]([CH2:36][CH2:37][O:8][C:6]2[CH:7]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=2[C:9]2[N:13]([CH2:14][CH:15]3[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]3)[C:12]3[CH:21]=[C:22]([F:26])[C:23]([F:25])=[CH:24][C:11]=3[N:10]=2)=[CH:32][CH:31]=1

Participants

3

Reactant 2

HCID 10586287Methyl 4-(2-bromoethyl)benzoateHCID 1363784785-chloro-2-(1-cyclohexylmethyl-5,6-difluoro-1H-benzoimidazol-2-yl)-phenol

Product 1

HCID 67049872HCID 67049872, compound

Procedure

The title compound was prepared in analogy to Example 5, intermediate a, from 5-chloro-2-(1-cyclohexylmethyl-5,6-difluoro-1H-benzoimidazol-2-yl)-phenol (Example 19, intermediate a) and 4-(2-bromo-ethyl)-benzoic acid methyl ester (CAS Reg. No. 136333-97-6). Colorless sticky solid (42%). MS (Turbo Spray): m/z=539.3 (M+H).

Sources & evidence

ORD record
ord-4f91aac9eb2543c4bcf587da2d79c883
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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