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4-(Toluene-4-sulfonyloxymethyl)-cyclohexanecarboxylic acid methyl ester → 4-[5-Chloro-2-(1-cyclohexylmethyl-5,6-difluoro-1H-benzoimidazol-2-yl)-phenoxymethyl]-cyclohexane carboxylic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(Toluene-4-sulfonyloxymethyl)-cyclohexanecarboxylic acid methyl ester | HCID 59460667 | — |
| 反応物 | 5-chloro-2-(1-cyclohexylmethyl-5,6-difluoro-1H-benzoimidazol-2-yl)-phenol | HCID 136378478 | — |
| 生成物 | 4-[5-Chloro-2-(1-cyclohexylmethyl-5,6-difluoro-1H-benzoimidazol-2-yl)-phenoxymethyl]-cyclohexane carboxylic acid methyl ester | HCID 67049710 | — |
反応手順
The title compound was prepared in analogy to Example 5, intermediate a, from 5-chloro-2-(1-cyclohexylmethyl-5,6-difluoro-1H-benzoimidazol-2-yl)-phenol (Example 19, intermediate a) and 4-(toluene-4-sulfonyloxymethyl)-cyclohexane carboxylic acid methyl ester (CAS Reg. No. 1003013-11-3). Brown solid (51%). MS (Turbo Spray): m/z=531.4 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08309581B2 |
| 出典データセット | uspto-grants-2012_11 |
| ORD ID | ord-fa0a505047e2483fad8d1b45400d17ad |
| 出典メモ | uspto-grants-2012_11 |