4-(Bromomethyl)-3-fluorobenzonitrile → HCID 67050099, compound

HRID 1875763Notes

Reaction equation

HRID 1875763 reaction equation
[CH:1]1([CH2:7][N:8]2[C:12]3[CH:13]=[C:14]([F:18])[C:15]([F:17])=[CH:16][C:11]=3[N:10]=[C:9]2[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[OH:25])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Br[CH2:27][C:28]1[CH:35]=[CH:34][C:31]([C:32]#[N:33])=[CH:30][C:29]=1[F:36]>>[CH:1]1([CH2:7][N:8]2[C:12]3[CH:13]=[C:14]([F:18])[C:15]([F:17])=[CH:16][C:11]=3[N:10]=[C:9]2[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[O:25][CH2:27][C:28]2[CH:35]=[CH:34][C:31]([C:32]#[N:33])=[CH:30][C:29]=2[F:36])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 27831494-(Bromomethyl)-3-fluorobenzonitrileHCID 136378489HCID 136378489, compound

Product 1

HCID 67050099HCID 67050099, compound

Procedure

The title compound was prepared in analogy to Example 5, intermediate a, from 2-(1-cyclohexylmethyl-5,6-difluoro-1H-benzoimidazol-2-yl)-phenol and 4-bromomethyl-3-fluoro-benzonitrile (105942-09-4). Brown sticky solid (69%). MS (Turbo Spray): m/z=476.4 (M+H).

Sources & evidence

ORD record
ord-f3c67ba22b954089b5f83ca1881f928d
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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