2-Methoxybenzoic acid → 5,6-Difluoro-2-(2-methoxyphenyl)-1H-benzo[D]imidazole

HRID 1875765Notes

Reaction equation

HRID 1875765 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([NH2:10])[C:5]([NH2:9])=[CH:6][C:7]=1[F:8].[CH3:11][O:12][C:13]1[CH:21]=[CH:20][CH:19]=[CH:18][C:14]=1[C:15](O)=O>>[F:1][C:2]1[C:7]([F:8])=[CH:6][C:5]2[NH:9][C:15]([C:14]3[CH:18]=[CH:19][CH:20]=[CH:21][C:13]=3[O:12][CH3:11])=[N:10][C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 113702-Methoxybenzoic acidHCID 27367551,2-Diamino-4,5-difluorobenzene

Product 1

HCID 609804125,6-Difluoro-2-(2-methoxyphenyl)-1H-benzo[D]imidazole

Procedure

The title compound was prepared in analogy to Example 19, intermediate c, from 4,5-difluoro-benzene-1,2-diamine (CAS Reg. No. 76179-40-3) and 2-methoxy-benzoic acid (CAS Reg. No. 579-75-9). Brown solid (41%). MS (Turbo Spray): m/z=261.2 (M+H).

Sources & evidence

ORD record
ord-10ec3b1c665d44c5b9326d58f04be4ca
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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