4-(Bromomethyl)-3-fluorobenzonitrile → HCID 67049797, compound

HRID 1875766Notes

Reaction equation

HRID 1875766 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:9]2[N:13]([CH2:14][CH:15]3[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]3)[C:12]3[CH:21]=[CH:22][CH:23]=[CH:24][C:11]=3[N:10]=2)=[C:6]([OH:8])[CH:7]=1.Br[CH2:26][C:27]1[CH:34]=[CH:33][C:30]([C:31]#[N:32])=[CH:29][C:28]=1[F:35]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:9]2[N:13]([CH2:14][CH:15]3[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]3)[C:12]3[CH:21]=[CH:22][CH:23]=[CH:24][C:11]=3[N:10]=2)=[C:6]([CH:7]=1)[O:8][CH2:26][C:27]1[CH:34]=[CH:33][C:30]([C:31]#[N:32])=[CH:29][C:28]=1[F:35]

Participants

3

Reactant 2

HCID 27831494-(Bromomethyl)-3-fluorobenzonitrileHCID 136378485HCID 136378485, compound

Product 1

HCID 67049797HCID 67049797, compound

Procedure

The title compound was prepared in analogy to Example 19, from 5-chloro-2-(1-cyclohexylmethyl-1H-benzoimidazol-2-yl)-phenol and 4-bromomethyl-3-fluoro-benzonitrile (105942-09-4). Brown solid (69%). MS (Turbo Spray): m/z=474.4 (M+H).

Sources & evidence

ORD record
ord-ff70c76cc5b94af6826c44d61510e8ba
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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