HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Diamino-4,5-difluorobenzene → 4-[2-(5,6-difluoro-1H-benzoimidazol-2-yl)-benzyloxy]-2-fluoro-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Diamino-4,5-difluorobenzene | HCID 2736755 | — |
| Reactant | 3-{4-[2-(2-Cyclopropylmethoxy-pyridin-3-yl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-phenyl}-propionic acid | HCID 51039679 | — |
| Reactant | 2-(4-Cyano-3-fluoro-phenoxymethyl)-benzoyl chloride | HCID 86652290 | — |
| Product | 4-[2-(5,6-difluoro-1H-benzoimidazol-2-yl)-benzyloxy]-2-fluoro-benzonitrile | HCID 67050112 | — |
Reaction Steps
The title compound was prepared in analogy to Example 40, intermediate b, from 2-(4-cyano-3-fluoro-phenoxymethyl)-benzoyl chloride and 4,5-difluoro-benzene-1,2-diamine (CAS Reg. No. 76179-40-3). Light yellow solid (15%). MS (Turbo Spray): m/z=380.2 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309581B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-17e8440a121b4f8e9e23602be579ad17 |
| Source note | uspto-grants-2012_11 |