2-Fluoro-4-hydroxybenzonitrile → HCID 67050010, compound

HRID 1875776Notes

Reaction equation

HRID 1875776 reaction equation
[F:1][C:2]1[CH:9]=[C:8]([OH:10])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[CH3:11][O:12][C:13](=[O:22])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[CH2:20]Br>>[CH3:11][O:12][C:13](=[O:22])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[CH2:20][O:10][C:8]1[CH:7]=[CH:6][C:3]([C:4]#[N:5])=[C:2]([F:1])[CH:9]=1

Participants

3

Reactant 2

HCID 27346752-Fluoro-4-hydroxybenzonitrileHCID 2734813Methyl 2-(bromomethyl)benzoate

Product 1

HCID 67050010HCID 67050010, compound

Procedure

The title compound was prepared in analogy to Example 40, intermediate e, from 2-fluoro-4-hydroxy-benzonitrile (CAS Reg. No. 82380-18-5) and 2-bromomethyl-benzoic acid methyl ester (CAS Reg. No. 2417-73-4). Off-white solid (91%). MS (Turbo Spray): m/z=286.1 (M+H).

Sources & evidence

ORD record
ord-e8381ca47b7d4d68b6fe79bbb8acc1a4
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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