4-(Bromomethyl)-3-fluorobenzonitrile → HCID 67049762, compound

HRID 1875777Notes

Reaction equation

HRID 1875777 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:9]2[N:13]([CH2:14][CH:15]3[CH2:19][CH2:18][CH2:17][CH2:16]3)[C:12]3[CH:20]=[C:21]([F:25])[C:22]([F:24])=[CH:23][C:11]=3[N:10]=2)=[C:6]([OH:8])[CH:7]=1.Br[CH2:27][C:28]1[CH:35]=[CH:34][C:31]([C:32]#[N:33])=[CH:30][C:29]=1[F:36]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:9]2[N:13]([CH2:14][CH:15]3[CH2:19][CH2:18][CH2:17][CH2:16]3)[C:12]3[CH:20]=[C:21]([F:25])[C:22]([F:24])=[CH:23][C:11]=3[N:10]=2)=[C:6]([CH:7]=1)[O:8][CH2:27][C:28]1[CH:35]=[CH:34][C:31]([C:32]#[N:33])=[CH:30][C:29]=1[F:36]

Participants

3

Reactant 2

HCID 27831494-(Bromomethyl)-3-fluorobenzonitrileHCID 136378500HCID 136378500, compound

Product 1

HCID 67049762HCID 67049762, compound

Procedure

The title compound was prepared in analogy to Example 5, intermediate a, from 5-chloro-2-(1-cyclopentylmethyl-5,6-difluoro-1H-benzoimidazol-2-yl)-phenol and 4-bromomethyl-3-fluoro-benzonitrile (CAS Reg. No. 105942-09-4). Brown solid (95%). MS (Turbo Spray): m/z=496.4 (M+H).

Sources & evidence

ORD record
ord-a4d77ceb1df6441598c63b744107a9eb
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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