4-(Bromomethyl)-3-fluorobenzonitrile → HCID 67049978, compound

HRID 1875779Notes

Reaction equation

HRID 1875779 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:9]2[N:13]([CH2:14][CH2:15][CH:16]3[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]3)[C:12]3[CH:22]=[C:23]([F:27])[C:24]([F:26])=[CH:25][C:11]=3[N:10]=2)=[C:6]([OH:8])[CH:7]=1.Br[CH2:29][C:30]1[CH:37]=[CH:36][C:33]([C:34]#[N:35])=[CH:32][C:31]=1[F:38]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:9]2[N:13]([CH2:14][CH2:15][CH:16]3[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]3)[C:12]3[CH:22]=[C:23]([F:27])[C:24]([F:26])=[CH:25][C:11]=3[N:10]=2)=[C:6]([CH:7]=1)[O:8][CH2:29][C:30]1[CH:37]=[CH:36][C:33]([C:34]#[N:35])=[CH:32][C:31]=1[F:38]

Participants

3

Reactant 2

HCID 27831494-(Bromomethyl)-3-fluorobenzonitrileHCID 136378476HCID 136378476, compound

Product 1

HCID 67049978HCID 67049978, compound

Procedure

The title compound was prepared in analogy to Example 5, intermediate a, from 5-chloro-2-[1-(2-cyclohexyl-ethyl)-5,6-difluoro-1H-benzoimidazol-2-yl]-phenol and 4-bromomethyl-3-fluoro-benzonitrile (CAS Reg. No. 105942-09-4). Brown sticky solid (81%). MS (Turbo Spray): m/z=524.0 (M+H).

Sources & evidence

ORD record
ord-95320d62679c467ea3de2ce71a4ee50c
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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