HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Bromomethyl)tetrahydro-2H-pyran → 2-(4-Chloro-2-methoxy-phenyl)-5,6-difluoro-1-(tetrahydro-pyran-2-ylmethyl)-1H-benzoimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Bromomethyl)tetrahydro-2H-pyran | HCID 141917 | — |
| Reactant | 3-{4-[2-(2-Cyclopropylmethoxy-pyridin-3-yl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-phenyl}-propionic acid | HCID 51039679 | — |
| Reactant | 2-[4-Chloro-2-(2-chloro-benzyloxy)-phenyl]-1-cyclohexylmethyl-5,6-difluoro-1H-benzoimidazole | HCID 58209272 | — |
| Product | 2-(4-Chloro-2-methoxy-phenyl)-5,6-difluoro-1-(tetrahydro-pyran-2-ylmethyl)-1H-benzoimidazole | HCID 67049999 | — |
Reaction Steps
The title compound was prepared in analogy to Example 19, intermediate b, from 2-(4-chloro-2-methoxy-phenyl)-5,6-difluoro-1H-benzoimidazole (Example 19, intermediate c) and 2-bromomethyl-tetrahydro-pyran (CAS Reg. No. 34723-82-5). Brown powder (39%). MS (Turbo Spray): m/z=393.2 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309581B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-11720e747db14fa588e38dd8d20f5df3 |
| Source note | uspto-grants-2012_11 |