1-Bromo-2,2-dimethylpropane → 2-(4-Chloro-2-methoxy-phenyl)-1-(2,2-dimethyl-propyl)-5,6-difluoro-1H-benzoimidazole

HRID 1875785Notes

Reaction equation

HRID 1875785 reaction equation
[CH:1]1(COC2C(C3N(CC4C=CC(CCC(O)=O)=CC=4)C4C=C(F)C(F)=CC=4N=3)=CC=CN=2)CC1.[Cl:35][C:36]1[CH:41]=[CH:40][C:39]([C:42]2[N:46]([CH2:47][CH:48]3[CH2:53]CCC[CH2:49]3)[C:45]3[CH:54]=[C:55]([F:59])[C:56]([F:58])=[CH:57][C:44]=3[N:43]=2)=[C:38]([O:60][CH2:61]C2C=CC=CC=2Cl)[CH:37]=1.BrCC(C)(C)C>>[Cl:35][C:36]1[CH:41]=[CH:40][C:39]([C:42]2[N:46]([CH2:47][C:48]([CH3:49])([CH3:1])[CH3:53])[C:45]3[CH:54]=[C:55]([F:59])[C:56]([F:58])=[CH:57][C:44]=3[N:43]=2)=[C:38]([O:60][CH3:61])[CH:37]=1

Participants

4

Reactant 3

HCID 124151-Bromo-2,2-dimethylpropaneHCID 510396793-{4-[2-(2-Cyclopropylmethoxy-pyridin-3-yl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-phenyl}-propionic acidHCID 582092722-[4-Chloro-2-(2-chloro-benzyloxy)-phenyl]-1-cyclohexylmethyl-5,6-difluoro-1H-benzoimidazole2×

Product 1

HCID 670499872-(4-Chloro-2-methoxy-phenyl)-1-(2,2-dimethyl-propyl)-5,6-difluoro-1H-benzoimidazole

Procedure

The title compound was prepared in analogy to Example 19, intermediate b, from 2-(4-chloro-2-methoxy-phenyl)-5,6-difluoro-1H-benzoimidazole (Example 19, intermediate c) and 1-bromo-2,2-dimethyl-propane (CAS Reg. No. 630-17-1). Light brown solid (20%). MS (Turbo Spray): m/z=365.1 (M+H).

Sources & evidence

ORD record
ord-110f47449f3947b29a2824c255c90b3b
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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