4-(Bromomethyl)oxane → 2-(4-Chloro-2-methoxy-phenyl)-5,6-difluoro-1-(tetrahydro-pyran-4-ylmethyl)-1H-benzoimidazole

Participants

Role	Name	HCID	Charge
Reactant	4-(Bromomethyl)oxane	HCID 2773286	—
Reactant	3-{4-[2-(2-Cyclopropylmethoxy-pyridin-3-yl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-phenyl}-propionic acid	HCID 51039679	—
Reactant	2-[4-Chloro-2-(2-chloro-benzyloxy)-phenyl]-1-cyclohexylmethyl-5,6-difluoro-1H-benzoimidazole	HCID 58209272	—
Product	2-(4-Chloro-2-methoxy-phenyl)-5,6-difluoro-1-(tetrahydro-pyran-4-ylmethyl)-1H-benzoimidazole	HCID 67049887	—

Reaction Steps

The title compound was prepared in analogy to Example 19, intermediate b, from 2-(4-chloro-2-methoxy-phenyl)-5,6-difluoro-1H-benzoimidazole (Example 19, intermediate c) and 4-bromomethyl-tetrahydro-pyran (CAS Reg. No. 125552-89-8). Light brown solid (29%). MS (Turbo Spray): m/z=393.3 (M+H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08309581B2
Source dataset	uspto-grants-2012_11
ORD ID	ord-107074736d0b43118da2a6de24a923ef
Source note	uspto-grants-2012_11