HuagongsheHuagongshe Chemistry Print Report · For research reference only
(Bromomethyl)cyclopentane → 1-(3-Chloro-benzyl)-2-(4-chloro-2-cyclopentylmethoxy-phenyl)-5,6-difluoro-1H-benzoimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (Bromomethyl)cyclopentane | HCID 12723264 | — |
| Reactant | 5-chloro-2-[1-(3-chloro-benzyl)-5,6-difluoro-1H-benzoimidazol-2-yl]-phenol | HCID 136378480 | — |
| Product | 1-(3-Chloro-benzyl)-2-(4-chloro-2-cyclopentylmethoxy-phenyl)-5,6-difluoro-1H-benzoimidazole | HCID 58209271 | — |
Reaction Steps
The title compound was prepared in analogy to Example 19, from 5-chloro-2-[1-(3-chloro-benzyl)-5,6-difluoro-1H-benzoimidazol-2-yl]-phenol (Example 53, intermediate a) and bromomethyl-cyclopentane (CAS Reg. No. 3814-30-0). Colorless powder (29%). MS (Turbo Spray): m/z=487.1 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309581B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-ff18b09c71914045b25463f8d77975be |
| Source note | uspto-grants-2012_11 |