HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromomethylcyclopropane → 1-(3-Chloro-benzyl)-2-(4-chloro-2-cyclopropylmethoxy-phenyl)-5,6-difluoro-1H-benzoimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromomethylcyclopropane | HCID 81503 | — |
| Reactant | 5-chloro-2-[1-(3-chloro-benzyl)-5,6-difluoro-1H-benzoimidazol-2-yl]-phenol | HCID 136378480 | — |
| Product | 1-(3-Chloro-benzyl)-2-(4-chloro-2-cyclopropylmethoxy-phenyl)-5,6-difluoro-1H-benzoimidazole | HCID 58209285 | — |
Reaction Steps
The title compound was prepared in analogy to Example 19, from 5-chloro-2-[1-(3-chloro-benzyl)-5,6-difluoro-1H-benzoimidazol-2-yl]-phenol (Example 53, intermediate a) and bromomethyl-cyclopropane (CAS Reg. No. 7051-34-5). Colorless powder (22%). MS (Turbo Spray): m/z=459.3 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309581B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-796522e6ed944d0a9f0167a382424b47 |
| Source note | uspto-grants-2012_11 |