(Bromomethyl)cyclopentane → HCID 67049948, compound

HRID 1875803Notes

Reaction equation

HRID 1875803 reaction equation
[CH3:1][O:2][C:3](=[O:31])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][N:12]2[C:16]3[CH:17]=[C:18]([F:22])[C:19]([F:21])=[CH:20][C:15]=3[N:14]=[C:13]2[C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][C:24]=2[OH:30])=[CH:7][CH:6]=1.Br[CH2:33][CH:34]1[CH2:38][CH2:37][CH2:36][CH2:35]1>>[CH3:1][O:2][C:3](=[O:31])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][N:12]2[C:16]3[CH:17]=[C:18]([F:22])[C:19]([F:21])=[CH:20][C:15]=3[N:14]=[C:13]2[C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][C:24]=2[O:30][CH2:33][CH:34]2[CH2:38][CH2:37][CH2:36][CH2:35]2)=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 12723264(Bromomethyl)cyclopentaneHCID 136378505HCID 136378505, compound

Product 1

HCID 67049948HCID 67049948, compound

Procedure

The title compound was prepared in analogy to Example 5, intermediate a, from {4-[2-(4-chloro-2-hydroxy-phenyl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-phenyl}-acetic acid methyl ester and bromomethyl-cyclopentane (CAS Reg. No. 3814-30-0). Brown sticky solid (61%). MS (Turbo Spray): m/z=525.4 (M+H).

Sources & evidence

ORD record
ord-bc64888cf30e4e129d40926b510ac935
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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