Methyl 2-(4-(bromomethyl)phenyl)acetate → {4-[2-(4-Chloro-2-methoxy-phenyl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-phenyl}-acetic acid methyl ester

HRID 1875804Notes

Reaction equation

HRID 1875804 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12](CC3C=CC(CCC(O)=O)=CC=3)[C:11]3[CH:25]=[C:26]([F:30])[C:27]([F:29])=[CH:28][C:10]=3[N:9]=2)=[C:4]([O:31][CH2:32]C2CCCC2)[CH:3]=1.ClC1C=CC(C2N(CC3C=C(C=CC=3)C(O)=O)C3C=C(F)C(F)=CC=3N=2)=C(OCC2CCCC2)C=1.[CH3:73][O:74][C:75](=[O:85])[CH2:76][C:77]1[CH:82]=[CH:81][C:80]([CH2:83]Br)=[CH:79][CH:78]=1>>[CH3:73][O:74][C:75](=[O:85])[CH2:76][C:77]1[CH:78]=[CH:79][C:80]([CH2:83][N:12]2[C:11]3[CH:25]=[C:26]([F:30])[C:27]([F:29])=[CH:28][C:10]=3[N:9]=[C:8]2[C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][C:4]=2[O:31][CH3:32])=[CH:81][CH:82]=1

Participants

4

Reactant 3

HCID 11770640Methyl 2-(4-(bromomethyl)phenyl)acetateHCID 582092583-{4-[2-(4-Chloro-2-cyclopentylmethoxy-phenyl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-phenyl}-propionic acidHCID 582092763-[2-(4-Chloro-2-cyclopentylmethoxy-phenyl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-benzoic acid2×

Product 1

HCID 67050026{4-[2-(4-Chloro-2-methoxy-phenyl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-phenyl}-acetic acid methyl ester

Procedure

The title compound was prepared in analogy to Example 19, intermediate b, from 2-(4-chloro-2-methoxy-phenyl)-5,6-difluoro-1H-benzoimidazole (Example 19, intermediate c) and (4-bromomethyl-phenyl)-acetic acid methyl ester (CAS Reg. No. 7398-42-7). Brown sticky solid (15%). MS (Turbo Spray): m/z=457.4 (M+H).

Sources & evidence

ORD record
ord-564f391d6c2f49e3bdf700a9a4b50829
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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