(Bromomethyl)cyclopentane → {4-[2-(4-Chloro-2-cyclopentylmethoxy-phenyl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-phenoxy}-acetic acid methyl ester

HRID 1875805Notes

Reaction equation

HRID 1875805 reaction equation
[CH3:1][O:2][C:3](=[O:32])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][N:13]2[C:17]3[CH:18]=[C:19]([F:23])[C:20]([F:22])=[CH:21][C:16]=3[N:15]=[C:14]2[C:24]2[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][C:25]=2[OH:31])=[CH:8][CH:7]=1.Br[CH2:34][CH:35]1[CH2:39][CH2:38][CH2:37][CH2:36]1>>[CH3:1][O:2][C:3](=[O:32])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][N:13]2[C:17]3[CH:18]=[C:19]([F:23])[C:20]([F:22])=[CH:21][C:16]=3[N:15]=[C:14]2[C:24]2[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][C:25]=2[O:31][CH2:34][CH:35]2[CH2:39][CH2:38][CH2:37][CH2:36]2)=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 12723264(Bromomethyl)cyclopentaneHCID 136378477{4-[2-(4-Chloro-2-hydroxy-phenyl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-phenoxy}-acetic acid methyl ester

Product 1

HCID 67050008{4-[2-(4-Chloro-2-cyclopentylmethoxy-phenyl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-phenoxy}-acetic acid methyl ester

Procedure

The title compound was prepared in analogy to Example 5, intermediate a, from {4-[2-(4-chloro-2-hydroxy-phenyl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-phenoxy}-acetic acid methyl ester and bromomethyl-cyclopentane (CAS Reg. No. 3814-30-0). Brown sticky solid (57%). MS (Turbo Spray): m/z=540.9 (M+H).

Sources & evidence

ORD record
ord-5a0ed0b42b054ac3915ca055d6000d20
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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