(Bromomethyl)cyclopentane → 6-[2-(4-Chloro-2-cyclopentylmethoxy-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-hexanoic acid methyl ester

HRID 1875807Notes

Reaction equation

HRID 1875807 reaction equation
[CH3:1][O:2][C:3](=[O:28])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][N:9]1[C:13]2[CH:14]=[C:15]([F:19])[C:16]([F:18])=[CH:17][C:12]=2[N:11]=[C:10]1[C:20]1[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][C:21]=1[OH:27].Br[CH2:30][CH:31]1[CH2:35][CH2:34][CH2:33][CH2:32]1>>[CH3:1][O:2][C:3](=[O:28])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][N:9]1[C:13]2[CH:14]=[C:15]([F:19])[C:16]([F:18])=[CH:17][C:12]=2[N:11]=[C:10]1[C:20]1[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][C:21]=1[O:27][CH2:30][CH:31]1[CH2:35][CH2:34][CH2:33][CH2:32]1

Participants

3

Reactant 2

HCID 12723264(Bromomethyl)cyclopentaneHCID 1363784916-[2-(4-Chloro-2-hydroxy-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-hexanoic acid methyl ester

Product 1

HCID 670501496-[2-(4-Chloro-2-cyclopentylmethoxy-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-hexanoic acid methyl ester

Procedure

The title compound was prepared in analogy to Example 5, intermediate a, from 6-[2-(4-chloro-2-hydroxy-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-hexanoic acid methyl ester and bromomethyl-cyclopentane (CAS Reg. No. 3814-30-0). Brown sticky solid (65%). MS (Turbo Spray): m/z=505.3 (M+H).

Sources & evidence

ORD record
ord-a84d107cda4c4122a26bced2c3e8eebb
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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