(Bromomethyl)cyclopentane → HCID 67049950, compound

HRID 1875809Notes

Reaction equation

HRID 1875809 reaction equation
[CH3:1][O:2][C:3]([CH:5]1[CH2:10][CH2:9][CH:8]([CH2:11][N:12]2[C:16]3[CH:17]=[C:18]([F:22])[C:19]([F:21])=[CH:20][C:15]=3[N:14]=[C:13]2[C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][C:24]=2[OH:30])[CH2:7][CH2:6]1)=[O:4].Br[CH2:32][CH:33]1[CH2:37][CH2:36][CH2:35][CH2:34]1>>[CH3:1][O:2][C:3]([CH:5]1[CH2:10][CH2:9][CH:8]([CH2:11][N:12]2[C:16]3[CH:17]=[C:18]([F:22])[C:19]([F:21])=[CH:20][C:15]=3[N:14]=[C:13]2[C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][C:24]=2[O:30][CH2:32][CH:33]2[CH2:37][CH2:36][CH2:35][CH2:34]2)[CH2:7][CH2:6]1)=[O:4]

Participants

3

Reactant 2

HCID 12723264(Bromomethyl)cyclopentaneHCID 136378492HCID 136378492, compound

Product 1

HCID 67049950HCID 67049950, compound

Procedure

The title compound was prepared in analogy to Example 5, intermediate a, from 4-[2-(4-chloro-2-hydroxy-phenyl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-cyclohexane carboxylic acid methyl ester and bromomethyl-cyclopentane (CAS Reg. No. 3814-30-0). Brown solid (56%). MS (Turbo Spray): m/z=517.4 (M+H).

Sources & evidence

ORD record
ord-14aabbc9dccb45d6ba9ecb7c0f989150
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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