HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Bromomethyl)benzonitrile → 4-[2-(4-Chloro-2-methoxy-phenyl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Bromomethyl)benzonitrile | HCID 86996 | — |
| Reactant | 3-{4-[2-(4-Chloro-2-cyclopentylmethoxy-phenyl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-phenyl}-propionic acid | HCID 58209258 | — |
| Reactant | 3-[2-(4-Chloro-2-cyclopentylmethoxy-phenyl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-benzoic acid | HCID 58209276 | — |
| Product | 4-[2-(4-Chloro-2-methoxy-phenyl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-benzonitrile | HCID 67050436 | — |
Reaction Steps
The title compound was prepared in analogy to Example 19, intermediate b, from 2-(4-chloro-2-methoxy-phenyl)-5,6-difluoro-1H-benzoimidazole (Example 19, intermediate c) and 4-bromomethyl-benzonitrile (CAS Reg. No. 17201-43-3). Brown solid (48%). MS (Turbo Spray): m/z=410.3 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309581B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-18b4a2f5c13b4ab3955f8480b6d81bab |
| Source note | uspto-grants-2012_11 |