(Bromomethyl)cyclopentane → HCID 67049678, compound

HRID 1875814Notes

Reaction equation

HRID 1875814 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH2:13][C:14]3[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[C:16]([F:22])[CH:15]=3)[C:11]3[CH:23]=[C:24]([F:28])[C:25]([F:27])=[CH:26][C:10]=3[N:9]=2)=[C:4]([OH:29])[CH:3]=1.Br[CH2:31][CH:32]1[CH2:36][CH2:35][CH2:34][CH2:33]1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH2:13][C:14]3[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[C:16]([F:22])[CH:15]=3)[C:11]3[CH:23]=[C:24]([F:28])[C:25]([F:27])=[CH:26][C:10]=3[N:9]=2)=[C:4]([O:29][CH2:31][CH:32]2[CH2:36][CH2:35][CH2:34][CH2:33]2)[CH:3]=1

Participants

3

Reactant 2

HCID 12723264(Bromomethyl)cyclopentaneHCID 136378482HCID 136378482, compound

Product 1

HCID 67049678HCID 67049678, compound

Procedure

The title compound was prepared in analogy to Example 19, from 4-[2-(4-chloro-2-hydroxy-phenyl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-2-fluoro-benzonitrile and bromomethyl-cyclopentane (CAS Reg. No. 3814-30-0). Colorless solid (50%). MS (Turbo Spray): m/z=496.3 (M+H).

Sources & evidence

ORD record
ord-8026d83fadd5421cb7da9ceb825effd3
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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