HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Cyano-3-fluorobenzyl bromide → 4-[2-(4-Chloro-2-methoxy-phenyl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-2-fluoro-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Cyano-3-fluorobenzyl bromide | HCID 2778466 | — |
| Reactant | 3-{4-[2-(4-Chloro-2-cyclopentylmethoxy-phenyl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-phenyl}-propionic acid | HCID 58209258 | — |
| Reactant | 3-[2-(4-Chloro-2-cyclopentylmethoxy-phenyl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-benzoic acid | HCID 58209276 | — |
| Product | 4-[2-(4-Chloro-2-methoxy-phenyl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-2-fluoro-benzonitrile | HCID 67049870 | — |
Reaction Steps
The title compound was prepared in analogy to Example 19, intermediate b, from 2-(4-chloro-2-methoxy-phenyl)-5,6-difluoro-1H-benzoimidazole (Example 19, intermediate c) and 4-bromomethyl-2-fluoro-benzonitrile (CAS Reg. No. 222978-03-2). Brown sticky solid (39%). MS (Turbo Spray): m/z=428.2 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309581B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-30e03cf9e58146dca1ddb6cb8367535f |
| Source note | uspto-grants-2012_11 |