Cyclohexane, (bromomethyl)- → HCID 67049952, compound

HRID 1875819Notes

Reaction equation

HRID 1875819 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH2:13][C:14]3[CH:19]=[CH:18][C:17](CCC(O)=O)=[CH:16][CH:15]=3)[C:11]3[CH:25]=[C:26]([F:30])[C:27]([F:29])=[CH:28][C:10]=3[N:9]=2)=[C:4](OCC2CCCC2)[CH:3]=1.[Br:38]C1C=C(Cl)C=CC=1C1NC2C=C(F)C(F)=CC=2N=1.BrCC1CCCCC1>>[Br:38][C:4]1[CH:3]=[C:2]([Cl:1])[CH:7]=[CH:6][C:5]=1[C:8]1[N:12]([CH2:13][CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[C:11]2[CH:25]=[C:26]([F:30])[C:27]([F:29])=[CH:28][C:10]=2[N:9]=1

Participants

4

Reactant 3

HCID 137636Cyclohexane, (bromomethyl)-HCID 582092583-{4-[2-(4-Chloro-2-cyclopentylmethoxy-phenyl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-phenyl}-propionic acidHCID 67049991HCID 67049991, compound

Product 1

HCID 67049952HCID 67049952, compound

Procedure

The title compound was prepared in analogy to Example 19, intermediate b, from 2-(2-bromo-4-chloro-phenyl)-5,6-difluoro-1H-benzoimidazole and bromomethyl-cyclohexane (CAS Reg. No. 2550-36-9). Off-white solid (60%). MS (Turbo Spray): m/z=440.2 (M+H).

Sources & evidence

ORD record
ord-bb5982f3c41249b5ae66a5fe03f9be47
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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