HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Ethynylbenzonitrile → 4-[2-(1-Cyclohexylmethyl-5,6-difluoro-1H-benzoimidazol-2-yl)-phenylethynyl]-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Ethynylbenzonitrile | HCID 4547245 | — |
| Reactant | 2-(2-bromo-phenyl)-1-cyclohexylmethyl-5,6-difluoro-1H-benzoimidazole | HCID 67049989 | — |
| Product | 4-[2-(1-Cyclohexylmethyl-5,6-difluoro-1H-benzoimidazol-2-yl)-phenylethynyl]-benzonitrile | HCID 67049873 | — |
Reaction Steps
The title compound was prepared in analogy to Example 72, intermediate a, from 2-(2-bromo-phenyl)-1-cyclohexylmethyl-5,6-difluoro-1H-benzoimidazole and 4-ethynyl-benzonitrile (CAS Reg. No. 3032-92-6). Off-white powder (30%). MS (Turbo Spray): m/z=452.4 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309581B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-6582fd7a8cca46429bb2d8f7a091e26c |
| Source note | uspto-grants-2012_11 |