HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromobenzoic acid → 2-(2-bromo-phenyl)-5,6-difluoro-1H-benzoimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromobenzoic acid | HCID 6940 | — |
| Reactant | 1,2-Diamino-4,5-difluorobenzene | HCID 2736755 | — |
| Reactant | 3-{4-[2-(4-Chloro-2-cyclopentylmethoxy-phenyl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-phenyl}-propionic acid | HCID 58209258 | — |
| Product | 2-(2-bromo-phenyl)-5,6-difluoro-1H-benzoimidazole | HCID 60981492 | — |
Reaction Steps
The title compound was prepared in analogy to Example 19, intermediate b, from 4,5-difluoro-benzene-1,2-diamine (CAS Reg. No. 76179-40-3) and 2-bromo-benzoic acid (CAS Reg. No. 88-65-3). Colorless powder (75%). MS (Turbo Spray): m/z=309.2 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309581B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-ea3a0aee2fb4418ca670b80c3ed81b61 |
| Source note | uspto-grants-2012_11 |