(2-Bromoethyl)cyclohexane → HCID 67049730, compound

HRID 1875837Notes

Reaction equation

HRID 1875837 reaction equation
ClC1C=CC(C2N(C[C:14]3[CH:19]=[CH:18][C:17]([CH2:20][CH2:21]C(O)=O)=[CH:16][CH:15]=3)C3C=C(F)C(F)=CC=3N=2)=C(OCC2CCCC2)C=1.C1(C[N:45]2[C:49]3[CH:50]=[CH:51][CH:52]=[CH:53][C:48]=3[N:47]=[C:46]2[C:54]2C=C[CH:57]=[CH:56][C:55]=2CCC2C=CC(OCC(O)=O)=CC=2)CCCCC1.[Br:73][CH2:74][CH2:75]C1CCCCC1>>[Br:73][C:74]1[CH:75]=[CH:57][CH:56]=[CH:55][C:54]=1[C:46]1[N:45]([CH2:21][CH2:20][CH:17]2[CH2:16][CH2:15][CH2:14][CH2:19][CH2:18]2)[C:49]2[CH:50]=[CH:51][CH:52]=[CH:53][C:48]=2[N:47]=1

Participants

4

Reactant 3

HCID 15440(2-Bromoethyl)cyclohexaneHCID 51042279HCID 51042279, compound2×HCID 582092583-{4-[2-(4-Chloro-2-cyclopentylmethoxy-phenyl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-phenyl}-propionic acid

Product 1

HCID 67049730HCID 67049730, compound

Procedure

The title compound was prepared in analogy to Example 19, intermediate b, from 2-(2-bromo-phenyl)-5,6-difluoro-1H-benzoimidazole (Example 79, intermediate f) and (2-bromo-ethyl)-cyclohexane (CAS Reg. No. 1647-26-3). Light yellow sticky solid (87%). MS (Turbo Spray): m/z=384.2 (M+H).

Sources & evidence

ORD record
ord-a78e3682df824c9fb3fe42bd538ceb8c
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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