Cyclohexane, (bromomethyl)- → HCID 67050151, compound

HRID 1875839Notes

Reaction equation

HRID 1875839 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH2:13][C:14]3[CH:19]=[CH:18][C:17](CCC(O)=O)=[CH:16][CH:15]=3)[C:11]3[CH:25]=[C:26]([F:30])[C:27]([F:29])=[CH:28][C:10]=3[N:9]=2)=[C:4](OCC2CCCC2)[CH:3]=1.ClC1C=CC(C2NC3C=C(F)C(F)=CC=3N=2)=C([N+:56]([O-:58])=[O:57])C=1.BrCC1CCCCC1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH2:13][CH:14]3[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]3)[C:11]3[CH:25]=[C:26]([F:30])[C:27]([F:29])=[CH:28][C:10]=3[N:9]=2)=[C:4]([N+:56]([O-:58])=[O:57])[CH:3]=1

Participants

4

Reactant 3

HCID 137636Cyclohexane, (bromomethyl)-HCID 582092583-{4-[2-(4-Chloro-2-cyclopentylmethoxy-phenyl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-phenyl}-propionic acidHCID 67050100HCID 67050100, compound

Product 1

HCID 67050151HCID 67050151, compound

Procedure

The title compound was prepared in analogy to Example 19, intermediate b, from 2-(4-Chloro-2-nitro-phenyl)-5,6-difluoro-1H-benzoimidazole and bromomethyl-cyclohexane (CAS Reg. No. 2550-36-9). Off-white powder (43%). MS (Turbo Spray): m/z=406.3 (M+H).

Sources & evidence

ORD record
ord-c9b27357b15447e090fd81cafe9b4ca0
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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