HCID 67049939, compound → HCID 178522170, compound

HRID 1875842Notes

Reaction equation

HRID 1875842 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:9]2[N:13]([CH2:14][CH:15]3[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]3)[C:12]3[CH:21]=[C:22]([F:26])[C:23]([F:25])=[CH:24][C:11]=3[N:10]=2)=[C:6]([NH2:8])[CH:7]=1.C[O:28][C:29](=O)[C:30]1[CH:35]=[CH:34][C:33]([C:36]2[NH:40][N:39]=[N:38][N:37]=2)=[C:32]([F:41])[CH:31]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:9]2[N:13]([CH2:14][CH:15]3[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]3)[C:12]3[CH:21]=[C:22]([F:26])[C:23]([F:25])=[CH:24][C:11]=3[N:10]=2)=[C:6]([NH:8][C:29](=[O:28])[C:30]2[CH:35]=[CH:34][C:33]([C:36]3[NH:40][N:39]=[N:38][N:37]=3)=[C:32]([F:41])[CH:31]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 67049939HCID 67049939, compoundHCID 178497605HCID 178497605, compound

Product 1

HCID 178522170HCID 178522170, compound

Procedure

The title compound was prepared in analogy to Example 84, from 5-chloro-2-(1-cyclohexylmethyl-5,6-difluoro-1H-benzoimidazol-2-yl)-phenylamine (Example 84, intermediate a) and 3-fluoro-4-(1H-tetrazol-5-yl)-benzoic acid methyl ester. Off-white powder (35%). MS (Turbo Spray): m/z=566.1 (M+H).

Sources & evidence

ORD record
ord-5d8cde2b69c649e58a65cfb6469610be
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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